PF-07247685

CAT: 0931-T79358-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T79358-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Endogenous Metabolite
Related Pathways
Metabolism
Bioactivity
PF-07247685, a potent BCKDC kinase (BDK) inhibitor (EC 50 = 2.2 nM), enhances the binding between BDK and the BCKDH E2 core subunit to block E1 phosphorylation. BDK regulation is crucial for BCKDH activity, which manages the rate-limiting step in the catabolism of branched-chain amino acids (BCAA) . Dysfunctional BCAA metabolism is linked to various cardiometabolic disorders such as heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07247685 has demonstrated an ability to improve cardiometabolic parameters and glucose tolerance in mice [1].
Molecular Formula
C21H20N2O3S
Molecular Weight
380.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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