PF-07247685

• Target:

  Endogenous Metabolite

• Related Pathways:

  Metabolism

• Bioactivity:

  PF-07247685, a potent BCKDC kinase (BDK) inhibitor (EC 50 = 2.2 nM), enhances the binding between BDK and the BCKDH E2 core subunit to block E1 phosphorylation. BDK regulation is crucial for BCKDH activity, which manages the rate-limiting step in the catabolism of branched-chain amino acids (BCAA) . Dysfunctional BCAA metabolism is linked to various cardiometabolic disorders such as heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07247685 has demonstrated an ability to improve cardiometabolic parameters and glucose tolerance in mice [1].

• Molecular Formula:

  C21H20N2O3S

• Molecular Weight:

  380.46

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C