DZD1516

• Target:

  EGFR

• Related Pathways:

  Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling

• Bioactivity:

  DZD1516, a potent and selective HER2 inhibitor (IC50 = 0.56 nM), demonstrates good blood-brain barrier permeability and exhibits antitumor activity in both central nervous system (CNS) and subcutaneous xenograft mouse models [1].

• Smiles:

  O(C=1C=2C(NC3=CC(C)=C(OC4=CC=5N(C=C4)N=CN5)C=C3)=NC=NC2C=C(OC)C1)[C@@H]6C(F)(F)CN(C)CC6

• Molecular Formula:

  C28H27F2N7O3

• Molecular Weight:

  547.56

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2387570-00-3