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GBD-9

CAT: 0931-T79139-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T79139-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2864408-92-2
Target
BTK, Molecular Glues, PROTACs
Related Pathways
Angiogenesis, PROTAC, Tyrosine Kinase/Adaptors
Bioactivity
GBD-9, a dual-mechanism degrader, effectively promotes the degradation of BTK and GSPT1 through recruitment of E3 ligase cereblon (CRBN) . As a PROTAC molecule, GBD-9 induces BTK degradation, while also acting as a molecular glue for GSPT1 degradation, demonstrating potent inhibition of cancer cell growth [1].
Smiles
NC1=C2C(N(N=C2C3=CC=C(OC4=CC=CC=C4)C=C3)[C@H]5CN(C(CCCCCCCCNC=6C=C7C(=CC6)C(=O)N(C7=O)C8C(=O)NC(=O)CC8)=O)CCC5)=NC=N1
Molecular Formula
C44H47N9O6
Molecular Weight
797.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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