GBD-9

• Target:

  BTK|||Molecular Glues|||PROTACs

• Related Pathways:

  Angiogenesis|||PROTAC|||Tyrosine Kinase/Adaptors

• Bioactivity:

  GBD-9, a dual-mechanism degrader, effectively promotes the degradation of BTK and GSPT1 through recruitment of E3 ligase cereblon (CRBN) . As a PROTAC molecule, GBD-9 induces BTK degradation, while also acting as a molecular glue for GSPT1 degradation, demonstrating potent inhibition of cancer cell growth [1].

• Smiles:

  NC1=C2C(N(N=C2C3=CC=C(OC4=CC=CC=C4)C=C3)[C@H]5CN(C(CCCCCCCCNC=6C=C7C(=CC6)C(=O)N(C7=O)C8C(=O)NC(=O)CC8)=O)CCC5)=NC=N1

• Molecular Formula:

  C44H47N9O6

• Molecular Weight:

  797.9

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2864408-92-2