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Antileishmanial agent-17

CAT: 0931-T78964-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T78964-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2934738-40-4
Target
Parasite
Related Pathways
Microbiology/Virology
Bioactivity
Antileishmanial agent-17, a coumarin hybrid, exhibits potent antileishmanial activity (IC50 <0.78 μM) while proving non-toxic to normal VERO cells. It specifically interacts with the folate pathway enzymes pteridine reductase and DHFR-TS. Efficacy against the promastigote form is highlighted by an IC50 value of 0.40 μM, and against the amastigote form, an IC50 of 0.68 μM, respectively.
Smiles
C(NCCCCCCN1C=C(CN2CCOCC2)N=N1)(=O)C3=CC=4C(=CC(OCCCC)=CC4)OC3=O
Molecular Formula
C27H37N5O5
Molecular Weight
511.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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