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NNZ 2591

CAT: 0931-T77995-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T77995-02Size:50 mg
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CAS Number
847952-38-9
Bioactivity
NNZ 2591, a synthetic analogue of cyclic glycine-proline (cGP), exhibits oral activity and the ability to cross the blood-brain barrier. This compound demonstrates neuroprotective properties following ischemic brain injury and improves motor function in a rat model of Parkinson's disease. NNZ 2591 holds research potential for ischemic brain injury and Angelman syndrome [1] [2] [3].
Smiles
C(C=C)[C@@]12N(C(=O)CNC1=O)CCC2
Molecular Formula
C10H14N2O2
Molecular Weight
194.23
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Nnz-2591

NNZ-2591 (cyclo-L-glycyl-L-2-allylproline) is an investigational synthetic analog of cyclic glycine-proline (cGP), a breakdown product of human insulin-like growth factor 1 (IGF-1), that has been chemically modified to increase its half-life, stability, and oral bioavailability. It is currently under development by Neuren Pharmaceuticals for the symptomatic treatment of Angelman, Phelan-McDermid, and Pitt Hopkins Syndromes. It was granted Orphan Drug Designation by the FDA in October 2019 and was granted a patent by the European Patent Office in December 2019. Clinical trials are expected to begin in 2020.

CAS Number847952-38-9
PubChem CID11735696
IUPAC Name(8aR)-8a-prop-2-enyl-3,6,7,8-tetrahydro-2H-pyrrolo[1,2-a]pyrazine-1,4-dione
Molecular FormulaC10H14N2O2
Molecular Weight194.23
XLogP0.3
Topological Polar Surface Area49.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count14
Formal Charge0
Complexity300
SMILES
C=CC[C@@]12CCCN1C(=O)CNC2=O
InChI
InChI=1S/C10H14N2O2/c1-2-4-10-5-3-6-12(10)8(13)7-11-9(10)14/h2H,1,3-7H2,(H,11,14)/t10-/m0/s1
InChIKey
WVKCGUOWPZAROG-JTQLQIEISA-N
Chemical Structure
2D Structure
2D structure of Nnz-2591
CAS: 847952-38-9
CID: 11735696
Formula: C10H14N2O2
MW: 194.23
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight194.23
XLogP30.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass194.105527694
Monoisotopic Mass194.105527694
Topological Polar Surface Area49.4 Ų
Heavy Atom Count14
Formal Charge0
Complexity300
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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