BML-278

• Target :

  Histone Methyltransferase|||Sirtuin

• Related Pathways :

  DNA Damage/DNA Repair|||Chromatin/Epigenetic

• Purity :

  >99.99%

• Bioactivity :

  BML-278 is a SIRT1 activator with an EC150 of 1 ?M. It increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, improving early embryonic development. BML-278 induces cell cycle arrest at the G1/S phase in primary human mesenchymal stromal cells, delaying senescence. It also reduces microtubule protein acetylation in U937 cells and increases mitochondrial density in mouse C2C12 myoblasts.

• Smiles :

  CCOC(=O)C1=CN(Cc2ccccc2)C=C(C1c1ccccc1)C(=O)OCC

• Molecular Formula :

  C24H25NO4

• Molecular Weight :

  391.46

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  120533-76-8