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Tarlatamab

CAT: 0931-T76986Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T76986Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2307488-83-9
Target
Gamma-secretase
Related Pathways
Proteases/Proteasome, Neuroscience, Stem Cells
Bioactivity
Tarlatamab (AMG-757) is a first-in-class, high-affinity bispecific T-cell engager (BiTE) antibody targeting delta-like ligand 3 (DLL3), a protein primarily expressed in small-cell lung cancer (SCLC) with minimal expression in normal tissues. It has dissociation constants (KDs) of 0.64 nM and 0.50 nM for DLL3 in human and nonhuman primates (NHP), respectively, and 14.9 nM and 12 nM for CD3 in human and NHP, accordingly. As a pioneering HLE BiTE immuno-oncology therapy for DLL3-expression SCLC, tarlatamab shows promising potential for research in this area [1].
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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