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Tebotelimab

CAT: 0931-T76985-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T76985-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2245725-04-4
Target
LAG-3
Related Pathways
Immunology/Inflammation
Bioactivity
Tebotelimab (MGD-013) is a bispecific antibody targeting PD-1 and LAG-3, classified as a human IgG4κ dual-affinity re-targeting (DART) molecule. It has binding affinities with EC50 values of 1.65 nM for PD-1 and 0.41 nM for LAG-3 on NS0 cells. The compound inhibits PD-1/PD-L1, PD-1/PD-L2, and LAG-3/HLA (MHC-II) interactions, as well as PD-1 signaling pathways, thereby reinvigorating exhausted T-cell responses and bolstering antitumor immunity [1] [2] [3].
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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