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Talacotuzumab

CAT: 0931-T76883-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T76883-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1826831-79-1
Target
Immunology/Inflammation related, Interleukin
Related Pathways
Immunology/Inflammation
Purity
0.9842
Bioactivity
Talacotuzumab (JNJ 56022473) is an IgG1 fully humanized CD123 neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has a high affinity for CD123, CD32b/c, CD16-158F and CD16-158V, with KD of 0.43 nM, 188 nM, 46 nM and 16.8 nM, respectively. Talacotuzumab inhibits IL-3 signaling in target cells by inhibiting IL-3 binding to CD123. Talacotuzumab induces mutations in the Fc region to increase affinity for CD16 (FCγriiia), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC) . Talacotuzumab inhibits leukemia cell growth in xenografted mouse models of acute myeloid leukemia (AML) .
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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