Coibamide A

CAT: 0931-T76506-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T76506-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1029227-48-2

Target

Autophagy, Apoptosis, VEGFR

Related Pathways

Tyrosine Kinase/Adaptors, Autophagy, Apoptosis, Angiogenesis

Bioactivity

Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, exhibits potent antiproliferative activity, induces autophagosome accumulation via an mTOR-independent mechanism, and triggers apoptosis. Furthermore, it inhibits VEGFA/VEGFR2 expression, effectively suppressing tumor growth in glioblastoma xenografts [1] [2].

Smiles

[H][C@@]1([C@@H](C)CC)N(C)C(=O)[C@H](COC)N(C)C(=O)[C@H]([C@@H](C)OC(=O)[C@@H](C)N(C)C(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C)NC1=O)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](COC)N(C)C(=O)[C@H](OC(=O)[C@H](C(C)C)N(C)C)C(C)C

Molecular Formula

C65H110N10O16

Molecular Weight

1287.63

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Alternative Products

Catalog	Name
GTR19036028-01	Coibamide A

Coibamide A

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