Murepavadin (TFA)

Murepavadin (TFA)

• UNSPSC Description: Murepavadin (POL7080) (TFA), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic. Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with MIC50 and MIC90 values both of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance[1][2].
• Target Antigen: Antibiotic; Bacterial
• Type: Peptides
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/murepavadin-tfa.html
• Purity: 99.83
• Solubility: H2O : 50 mg/mL (ultrasonic)
• Smiles: O=C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@@](CCC1)([H])C(N2C(CCC2)([H])C(N[C@@](C(N3)=O)([H])[C@H](O)C)=O)=O)=O)CO)=O)C)=O)CCN)=O)CCN)=O)CC4=CNC5=CC=CC=C45)=O)CCN)=O)CCN)=O)CCCN)=O)CCN)=O)([H])[C@@H](C)CC)[C@@H]3CC6=CNC7=CC=CC=C67.O=C(O)C(F)(F)F
• Molecular Weight: 1667.83
• References & Citations: [1]Matteo Bassetti, et al. New antibiotics for ventilator-associated pneumonia. Curr Opin Infect Dis. 2018 Jan 13.|[2]Ignacio Martin-Loeches, et al. Murepavadin: a new antibiotic class in the pipeline. Expert Rev Anti Infect Ther. 2018 Apr;16(4):259-268.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
• Clinical Information: Phase 3