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Urocortin III (human)

CAT: 0931-T76180-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0931-T76180-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
357952-09-1
Target
CRFR
Related Pathways
GPCR/G Protein
Bioactivity
Urocortin III (human) is a corticotropin-releasing factor (CRF) -related peptide that primarily interacts with and activates the CRF receptor type 2 (CRF-R2), showing a specific distribution in the central nervous system and periphery. It selectively binds to type 2 CRF receptors with dissociation constants (Ki values) of 13.5 nM for mouse CRF2β, 21.7 nM for rat CRF2α, and >100 nM for human CRF1, indicating a strong preference for CRF-R2 over CRF1. Additionally, Urocortin III (human) plays a crucial role in the somatostatin-dependent negative feedback mechanism regulating the secretion of Insulin (human) .
Molecular Formula
C185H307N53O50S2
Molecular Weight
4137.93
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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