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Dehydrobruceine B

CAT: 0931-T75485-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T75485-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
53730-90-8
Target
Nrf2, Others, Apoptosis, Bcl-2 Family
Related Pathways
Apoptosis, Others, Immunology/Inflammation
Bioactivity
Dehydrobruceine B, a quassinoid isolated from Brucea javanica, demonstrates a synergistic effect with Cisplatin in inducing apoptosis through the mitochondrial pathway. It enhances the expression of apoptosis-inducing factor (AIF) and Bax while inhibiting Keap1-Nrf2 [1].
Smiles
C(OC)(=O)[C@]12[C@]3([C@]4([C@@]([C@]5(C)C(C[C@]4(OC(=O)[C@@H]3OC(C)=O)[H])=C(C)C(=O)C(O)=C5)([C@@H](O)[C@@H]1O)[H])CO2)[H]
Molecular Formula
C23H26O11
Molecular Weight
478.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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