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Foslevcromakalim

CAT: 0931-T75084Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T75084Size:2 mg
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CAS Number
1802655-72-6
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Bioactivity
Foslevcromakalim (QLS-101) is an adenosine triphosphate-sensitive potassium channel (KATP) opener that is converted to its active form by alkaline phosphatase in vivo. It reduces intraocular pressure in normotensive mice and is suitable for glaucoma research.
Smiles
O(P(=O)(O)O)[C@H]1[C@@H](C=2C(OC1(C)C)=CC=C(C#N)C2)N3C(=O)CCC3
Molecular Formula
C16H19N2O6P
Molecular Weight
366.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Foslevcromakalim

Foslevcromakalim is a small molecule drug. The usage of the INN stem '-kalim' in the name indicates that Foslevcromakalim is a potassium channel activator, antihypertensive. Foslevcromakalim has a monoisotopic molecular weight of 366.1 Da.

CAS Number1802655-72-6
PubChem CID91826794
IUPAC Name[(3S,4R)-6-cyano-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dihydrochromen-3-yl] dihydrogen phosphate
Molecular FormulaC16H19N2O6P
Molecular Weight366.30
XLogP-0.3
Topological Polar Surface Area120
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity638
SMILES
CC1([C@H]([C@@H](C2=C(O1)C=CC(=C2)C#N)N3CCCC3=O)OP(=O)(O)O)C
InChI
InChI=1S/C16H19N2O6P/c1-16(2)15(24-25(20,21)22)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)23-16/h5-6,8,14-15H,3-4,7H2,1-2H3,(H2,20,21,22)/t14-,15+/m1/s1
InChIKey
JRUHOGHWZXTUMZ-CABCVRRESA-N
Chemical Structure
2D Structure
2D structure of Foslevcromakalim
CAS: 1802655-72-6
CID: 91826794
Formula: C16H19N2O6P
MW: 366.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight366.30
XLogP3-0.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass366.09807333
Monoisotopic Mass366.09807333
Topological Polar Surface Area120 Ų
Heavy Atom Count25
Formal Charge0
Complexity638
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA6923-1Foslevcromakalim

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