Apratoxin S4

CAT: 0931-MF-0155034-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0155034-01Size:5 mg
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CAS Number
1334149-94-8
Target
Others
Related Pathways
Others
Bioactivity
Apratoxin S4 (Apra S4), a potent inhibitor of Sec61, disrupts the cotranslational translocation of secretory proteins into the endoplasmic reticulum (ER), showcasing antiviral efficacy against select flaviviruses with IC 50 values spanning 0.46 nM to 170 nM. It also curtails retinal vascular cell activation by targeting various angiogenic pathways. This compound is valuable for investigating viral infections, angiogenic diseases, and cancers [1] [2].
Smiles
O=C1N2[C@](C(=O)O[C@H]([C@@](C)(C)C)C[C@@H](C)C[C@H](O)[C@H](C)C3=N[C@](CS3)(CCC(=O)N[C@@H](CC4=CC=C(OC)C=C4)C(=O)N(C)[C@@H](C)C(=O)N(C)[C@]1([C@H](CC)C)[H])[H])(CCC2)[H]
Molecular Formula
C44H69N5O8S
Molecular Weight
828.11
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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