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GSK3735967

CAT: 0931-T74887-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74887-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2170136-86-2
Target
Others, DNA Methyltransferase
Related Pathways
Others, Chromatin/Epigenetic
Bioactivity
GSK3735967 is a selective, reversible, non-nucleoside inhibitor targeting DNMT1, demonstrating an IC50 value of 40 nM. It features a planar dicyanopyridine core designed to specifically interact with DNMT1-bound hemimethylated CpG dinucleotides. Additionally, GSK3735967 possesses three binding sites, with one uniquely capable of binding to histone H4K20me3 [1] [2].
Smiles
C(#N)C1=C(N=C(SCC2=CC=C(CNC(CN)=O)C=C2)C(C#N)=C1CC)N3CCN(C)CCC3
Molecular Formula
C25H31N7OS
Molecular Weight
477.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
BA4649-1GSK3735967

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