TAM470

CAT: 0931-T74648-02Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0931-T74648-02Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1802498-63-0

Target

Microtubule Associated, ADC Cytotoxin

Related Pathways

Cytoskeletal Signaling, Antibody-drug Conjugate/ADC Related

Bioactivity

TAM470, a novel cytolysin, inhibits both tubulin polymerization and microtubule depolymerization. It serves as a precursor in the synthesis of OMTX705, a payload molecule. OMTX705 represents a new class of FAP-targeting antibody-drug conjugates (ADCs) exhibiting antitumor activity [1].

Smiles

CCCO[C@H](C[C@H](C(C)C)N(CCC)C(=O)[C@@H](NC(=O)[C@H]1CCCCN1C)[C@@H](C)CC)c1nc(cs1)C(=O)N[C@H](C[C@H](C)C(=O)NN)Cc1ccc(O)cc1

Molecular Formula

C41H67N7O6S

Molecular Weight

786.08

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

CID 118284090

CAS Number	1802498-63-0
PubChem CID	118284090
IUPAC Name	N-[(2R,4S)-5-hydrazinyl-1-(4-hydroxyphenyl)-4-methyl-5-oxopentan-2-yl]-2-[(1R,3R)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]-propylamino]-1-propoxypentyl]-1,3-thiazole-4-carboxamide
Molecular Formula	C41H67N7O6S
Molecular Weight	786.1
XLogP	6.4
Topological Polar Surface Area	207
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	22
Heavy Atom Count	55
Formal Charge	0
Complexity	1190

SMILES

CCCN([C@H](C[C@H](C1=NC(=CS1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C[C@H](C)C(=O)NN)OCCC)C(C)C)C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]3CCCCN3C

InChI

InChI=1S/C41H67N7O6S/c1-9-19-48(41(53)36(27(6)11-3)45-39(52)33-14-12-13-20-47(33)8)34(26(4)5)24-35(54-21-10-2)40-44-32(25-55-40)38(51)43-30(22-28(7)37(50)46-42)23-29-15-17-31(49)18-16-29/h15-18,25-28,30,33-36,49H,9-14,19-24,42H2,1-8H3,(H,43,51)(H,45,52)(H,46,50)/t27-,28-,30+,33+,34+,35+,36-/m0/s1

InChIKey

WZNRAPVOSYSOAK-WPIAVMABSA-N

Chemical Structure

2D Structure

CAS: 1802498-63-0

CID: 118284090

Formula: C41H67N7O6S

MW: 786.1

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	786.1
XLogP3	6.4
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	22
Exact Mass	785.48735406
Monoisotopic Mass	785.48735406
Topological Polar Surface Area	207 Å²
Heavy Atom Count	55
Formal Charge	0
Complexity	1190
Isotope Atom Count	0
Defined Atom Stereocenter Count	7
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
GTR19221061-01	TAM470

TAM470

Chemical Information

Alternative Products

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