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DB0614

CAT: 0931-T74644-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74644-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2769753-47-9
Target
AAK1 (AP2 associated kinase 1), Ferroptosis, PROTACs, CaMK, LIM Kinase, Aurora Kinase, Autophagy, CDK, SIK
Related Pathways
PROTAC, Chromatin/Epigenetic, Cell Cycle/Checkpoint, Neuroscience, Autophagy, PI3K/Akt/mTOR signaling, Apoptosis
Bioactivity
DB0614 (Example 21) is a bifunctional compound designed for the targeted degradation of kinases, effectively breaking down AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK, LCK, LIMK2, MAP3KH, MAPK8, MAPK9, NEK9, PLK4, PTK2B, SIK2, STK17A, STK17B, ULK1, ULK3, and WEE1. This compound has potential applications in research on diseases or disorders caused by aberrant kinase activity [1].
Smiles
CS(=O)(=O)Nc1cccc(c1)-c1csc2cnc(Nc3ccc(cc3)N3CCN(CCCCCOc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)nc12
Molecular Formula
C41H42N8O7S2
Molecular Weight
822.95
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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