SJ1008030

• Target :

  Others|||JAK|||PROTACs

• Related Pathways :

  Tyrosine Kinase/Adaptors|||Angiogenesis|||PROTAC|||JAK/STAT signaling|||Stem Cells|||Others|||Chromatin/Epigenetic

• Bioactivity :

  SJ1008030 (compound 8), a JAK2 PROTAC, selectively degrades JAK2. It demonstrates potent activity against MHH–CALL-4 cells, with an EC50 of 5.4 nM and an IC50 of 32.09 nM. This compound holds potential for leukemia research [1].

• Smiles :

  CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1nc(Nc2ccc(cc2)C(=O)NCCN2CCN(CC2)c2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)nc2[nH]ccc12

• Molecular Formula :

  C42H43N13O7S

• Molecular Weight :

  873.94

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2863634-96-0