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DIZ-3

CAT: 0931-T74539-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74539-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2675490-72-7
Target
Others, DNA/RNA Synthesis
Related Pathways
Others, DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Bioactivity
DIZ-3, a selective multimeric G-quadruplex (G4) ligand, employs a G4-ligand-dimerizing approach to intercalate into the G4-G4 interface, thereby stabilizing its higher-order structure. This compound effectively induces cell cycle arrest and apoptosis, inhibiting cell proliferation in cancer cells characterized by alternative lengthening of telomeres (ALT) [1].
Smiles
CN1CCN(CC1)c1ccc(cc1)-c1[nH]c(nc1-c1ccc(F)cc1)-c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(cc1)N1CCN(C)CC1)-c1ccc(F)cc1
Molecular Formula
C46H44F2N8
Molecular Weight
746.89
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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