HD-TAC7

• Target:

  PROTACs|||HDAC

• Related Pathways:

  DNA Damage/DNA Repair|||PROTAC|||Chromatin/Epigenetic

• Bioactivity:

  HD-TAC7, a potent PROTAC HDAC degrader, exhibits IC50 values of 3.6 ?M, 4.2 ?M, and 1.1 ?M for HDAC1, HDAC2, and HDAC3, respectively. It effectively decreases NF-?B p65 in RAW 264.7 macrophages and is utilized in research targeting inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD) [1].

• Smiles:

  O=C (NC1=CC=C (F) C=C1N) C2=CC=C (C=C2) NC (=O) CCCCNC (=O) CNC3=CC=CC=4C (=O) N (C (=O) C34) C5C (=O) NC (=O) CC5

• Molecular Formula:

  C33H32FN7O7

• Molecular Weight:

  657.65

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2978763-95-8