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HD-TAC7

CAT: 0931-T74514-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T74514-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2978763-95-8
Target
PROTACs|||HDAC
Related Pathways
DNA Damage/DNA Repair|||PROTAC|||Chromatin/Epigenetic
Bioactivity
HD-TAC7, a potent PROTAC HDAC degrader, exhibits IC50 values of 3.6 ?M, 4.2 ?M, and 1.1 ?M for HDAC1, HDAC2, and HDAC3, respectively. It effectively decreases NF-?B p65 in RAW 264.7 macrophages and is utilized in research targeting inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD) [1].
Smiles
O=C(NC1=CC=C(F)C=C1N)C2=CC=C(C=C2)NC(=O)CCCCNC(=O)CNC3=CC=CC=4C(=O)N(C(=O)C34)C5C(=O)NC(=O)CC5
Molecular Formula
C33H32FN7O7
Molecular Weight
657.65
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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