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W1131

CAT: 0931-T73558-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T73558-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2740522-79-4
Target
Ferroptosis, OXPHOS, STAT, Others
Related Pathways
Others, JAK/STAT signaling, Apoptosis, Stem Cells
Bioactivity
W1131, a potent STAT3 inhibitor, effectively triggers ferroptosis and suppresses cancer progression across various models including gastric cancer cell subcutaneous xenograft, organoids, and patient-derived xenograft (PDX) . Additionally, W1131 overcomes chemical resistance in cancer cells to 5-FU by regulating cell cycle, DNA damage response, and oxidative phosphorylation pathways, notably the IL6-JAK-STAT3 and ferroptosis pathways [1].
Smiles
N(C(=O)C=1OC(N(=O)=O)=CC1)C2=CC=C(C=3N4C(C=C(C=C4)C=5CCNCC5)=NC3)C=C2
Molecular Formula
C23H19N5O4
Molecular Weight
429.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
BA3421-5W1131
MBS5822502W1131 TFA
HY-153190A-01W1131 (TFA)

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