W1131

• Target :

  Ferroptosis|||OXPHOS|||STAT|||Others

• Related Pathways :

  Others|||JAK/STAT signaling|||Apoptosis|||Stem Cells

• Bioactivity :

  W1131, a potent STAT3 inhibitor, effectively triggers ferroptosis and suppresses cancer progression across various models including gastric cancer cell subcutaneous xenograft, organoids, and patient-derived xenograft (PDX) . Additionally, W1131 overcomes chemical resistance in cancer cells to 5-FU by regulating cell cycle, DNA damage response, and oxidative phosphorylation pathways, notably the IL6-JAK-STAT3 and ferroptosis pathways [1].

• Smiles :

  N(C(=O)C=1OC(N(=O)=O)=CC1)C2=CC=C(C=3N4C(C=C(C=C4)C=5CCNCC5)=NC3)C=C2

• Molecular Formula :

  C23H19N5O4

• Molecular Weight :

  429.43

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2740522-79-4