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AS-99

CAT: 0931-T73529-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T73529-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Others, Apoptosis, Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic, Apoptosis, Others
Bioactivity
AS-99 is a first-in-class, potent, and selective inhibitor of the ASH1L histone methyltransferase, displaying anti-leukemic activity with an IC50 of 0.79 μM and a Kd of 0.89 μM. It inhibits cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and effectively reduces leukemia burden [in vivo].
Smiles
CN1CC(C(NCC2=CC3=C(C(C4=CC(C(N)=S)=CC=C4)=CN3C5CCN(S(=O)(C(F)(F)F)=O)CC5)C=C2)=O)C1.Cl
Molecular Formula
C27H31ClF3N5O3S2
Molecular Weight
630.14
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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