AS-99

• Target :

  Others|||Apoptosis|||Histone Methyltransferase

• Related Pathways :

  Chromatin/Epigenetic|||Apoptosis|||Others

• Bioactivity :

  AS-99 is a first-in-class, potent, and selective inhibitor of the ASH1L histone methyltransferase, displaying anti-leukemic activity with an IC50 of 0.79 µM and a Kd of 0.89 µM. It inhibits cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and effectively reduces leukemia burden [in vivo].

• Smiles :

  CN1CC(C(NCC2=CC3=C(C(C4=CC(C(N)=S)=CC=C4)=CN3C5CCN(S(=O)(C(F)(F)F)=O)CC5)C=C2)=O)C1.Cl

• Molecular Formula :

  C27H31ClF3N5O3S2

• Molecular Weight :

  630.14

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C