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JMX0293

CAT: 0931-T73419-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T73419-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, Others
Related Pathways
Apoptosis, Others
Bioactivity
JMX0293, an O-alkylamino-tethered salicylamide derivative, demonstrates strong efficacy against the TNBC MDA-MB-231 cell line with an IC50 of 3.38 μM, while showing minimal toxicity towards the non-tumorigenic human breast epithelial cell line MCF-10A, where its IC50 exceeds 60 μM. It inhibits STAT3 phosphorylation, contributing to apoptosis in MDA-MB-231 cells, and significantly suppresses MDA-MB-231 xenograft tumor growth in vivo, all without notable toxicity.
Smiles
CC(OC(NCCOC1=C(C=C(C=C1)Cl)C(N[C@@H](C(C)C)C(NC2=C(C=C(C=C2)[N+]([O-])=O)Cl)=O)=O)=O)(C)C
Molecular Formula
C25H30Cl2N4O7
Molecular Weight
569.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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