PV-1019

• Target:

  Chk|||Others

• Related Pathways:

  Cell Cycle/Checkpoint|||Others

• Bioactivity:

  PV-1019 (NSC 744039) is a potent and selective inhibitor of Chk2 with an IC50 of 24 nM, effectively inhibiting Topotecan-induced Chk2 autophosphorylation and suppressing IR-induced apoptosis [1].

• Smiles:

  N(=O)(=O)C1=C2C(C=C(C(NC3=CC=C(C(=NNC(=N)N)C)C=C3)=O)N2)=CC=C1

• Molecular Formula:

  C18H17N7O3

• Molecular Weight:

  379.37

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1093793-05-5