DOCK2-IN-1

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  DOCK2-IN-1, an analogue of CPYPP, effectively inhibits DOCK2 (IC50 = 19.1 ?M) by reversibly binding to its DHR-2 domain, thereby hindering its catalytic function. This compound obstructs the activation of Rac in lymphocytes, triggered either by chemokine or antigen receptors. Consequently, DOCK2-IN-1 markedly reduces chemotactic responses and T cell activation [1].

• Smiles:

  O=C1N (NC (=O) C1=CC2=C (Cl) C=CC=C2) C3=CC=CC=C3

• Molecular Formula:

  C16H11ClN2O2

• Molecular Weight:

  298.72

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  4590-86-7