SIRT2-IN-11

CAT: 0931-T73000-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T73000-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1005095-06-6

Target

Others, Sirtuin

Related Pathways

Others, DNA Damage/DNA Repair, Chromatin/Epigenetic

Bioactivity

SIRT2-IN-11 (AEM1) is a selective inhibitor of SIRT2 with an inhibitory concentration (IC50) of 18.5 μM. It induces apoptosis in a p53-dependent manner, activates the expression of CDKN1A, PUMA, and NOXA, and enhances the acetylation of p53. This compound is utilized in the study of p53-associated cancers.

Smiles

C(N)(=O)C=1C=C2C3C(C(NC2=CC1)C4=CC=CC=C4)C5CC3CC5

Molecular Formula

C21H22N2O

Molecular Weight

318.41

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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