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Efonidipine hydrochloride

CAT: 0931-T72213-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T72213-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
111011-53-1
Target
Calcium Channel, Others
Related Pathways
Metabolism, Others, Membrane transporter/Ion channel
Bioactivity
Efonidipine HCl (NZ-105) serves as both a T-type and L-type calcium channel blocker. This compound, distinct from other calcium channel blockers, notably increases N (6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (dbcAMP) -induced StAR mRNA and DHEA-S production in NCI-H295R adrenocortical carcinoma cells, actions reflective of adrenocorticotropic hormone. Efonidipine uniquely inhibits calcium channels by merging tonic and use-dependent blocking methods. Its inhibitory concentrations (IC50) for I (Ca (T) ) and I (Ca (L) ) are 0.35 micromol/l and 1.8 nmol/l, respectively. Clinically, efonidipine administered to hypertensive patients undergoing chronic hemodialysis (20-60 mg, twice daily) demonstrated comparable blood pressure control to amlodipine (2.5-7.5 mg, once daily) over a 12-week period without significantly altering pulse rate. Furthermore, efonidipine significantly improved left ventricular ejection fraction in heart failure models without affecting blood pressure, in addition to lowering the heart rate by about 10%.
Smiles
Cl.O=C(OCCN(C=1C=CC=CC1)CC=2C=CC=CC2)C3=C(NC(=C(C3C=4C=CC=C(C4)N(=O)=O)P5(=O)OCC(C)(C)CO5)C)C
Molecular Formula
C34H39ClN3O7P
Molecular Weight
668.12
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Efonidipine Hydrochloride

See also: Efonidipine (has active moiety).

CAS Number111011-53-1
PubChem CID119170
IUPAC Name2-(N-benzylanilino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate;hydrochloride
Molecular FormulaC34H39ClN3O7P
Molecular Weight668.1
Topological Polar Surface Area123
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count10
Heavy Atom Count46
Formal Charge0
Complexity1170
SMILES
CC1=C(C(C(=C(N1)C)P2(=O)OCC(CO2)(C)C)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5.Cl
InChI
InChI=1S/C34H38N3O7P.ClH/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45;/h5-17,20,31,35H,18-19,21-23H2,1-4H3;1H
InChIKey
OXVTXPCIJDYQIS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Efonidipine Hydrochloride
CAS: 111011-53-1
CID: 119170
Formula: C34H39ClN3O7P
MW: 668.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight668.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count10
Exact Mass667.2214153
Monoisotopic Mass667.2214153
Topological Polar Surface Area123 Ų
Heavy Atom Count46
Formal Charge0
Complexity1170
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
sc-294464AEfonidipine hydrochloride
HY-12502BEfonidipine (hydrochloride)
MBS3600410-01Efonidipine hydrochloride monoethanolate
A21431-25Efonidipine hydrochloride 25mg
A21431-100Efonidipine hydrochloride 100mg
A21431-50Efonidipine hydrochloride 50mg
HY-12502A-01Efonidipine (hydrochloride monoethanolate)
A21431-10Efonidipine hydrochloride 10mg

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