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Sotuletinib hydrochloride

CAT: 0931-T72211-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T72211-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2222138-31-8
Target
C-Fms, CSF-1R
Related Pathways
Tyrosine Kinase/Adaptors
Purity
0.98812
Bioactivity
Sotuletinib hydrochloride (BLZ945 HCl) is a selective, brain-penetrant CSF-1R (c-Fms) inhibitor (IC50=1 nM), exhibiting 1000-fold greater selectivity than other receptor tyrosine kinase homologues. It elevates liver enzymes and induces Kupffer cell depletion, making it suitable for studying amyotrophic lateral sclerosis (ALS) and metastatic triple-negative breast cancer (TNBC) .
Smiles
N(C=1SC=2C(N1)=CC=C(OC=3C=C(C(NC)=O)N=CC3)C2)[C@H]4[C@H](O)CCCC4.Cl
Molecular Formula
C20H23ClN4O3S
Molecular Weight
434.94
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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