BI-2865

CAT: 0931-T72062-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T72062-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2937327-93-8
Target
Kras|||Ras
Related Pathways
GPCR/G Protein|||MAPK
Purity
0.9939
Bioactivity
BI-2865 is a non-covalent pan-KRAS inhibitor.BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD values of 6.9, 4.5, 32, 26, and 4.3 nM, respectively.BI-2865 showed antiproliferative activity in BaF3 cells expressing KRAS G12C, G12D, or G12V mutants[1] . BI-2865 showed antiproliferative activity on BaF3 cells expressing KRAS G12C, G12D or G12V mutants, with an average IC50 value of approximately 140 nM.[1]
Smiles
C[C@]1(C2=C(SC(N)=C2C#N)CCC1)C3=NC(=NO3)C=4N=C(O[C@@H](C)[C@@]5(CCCN5C)[H])C=CN4
Molecular Formula
C23H27N7O2S
Molecular Weight
465.57
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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