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6 (5H) -Phenanthridinone

CAT: 0931-T72017-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T72017-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1015-89-0
Target
Others, PARP
Related Pathways
Others, Chromatin/Epigenetic, DNA Damage/DNA Repair
Bioactivity
6 (5H) -Phenanthridinone is an inhibitor of poly (ADP-ribose) polymerase 1 (PARP1) and PARP2. It decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells. 6 (5H) -Phenanthridinone reduces NF-κB-induced transcription of the genes encoding TNF-α, IL-2, and IFN-γ in rat lymphocytes. In vivo, 6 (5H) -phenanthridinone reduces spinal cord expression of inducible nitric oxide synthase (iNOS), IL-1β, TNF-α, IL-2, and IFN-γ and reduces disease score in a rat model of experimental autoimmune encephalomyelitis (EAE) . It also decreases serum levels of lactate dehydrogenase as well as hepatic lipid peroxidation, oxidative DNA damage, and PARP levels.
Smiles
O=C1NC2=C(C=CC=C2)C2=C1C=CC=C2
Molecular Formula
C13H9NO
Molecular Weight
195.22
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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