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G-573

CAT: 0931-T71891-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T71891-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
22868-35-5
Target
Others
Related Pathways
Others
Bioactivity
G-573 is an allosteric inhibitor of MEK that is both potent and selective. The IC (50) value for pERK inhibition in HCT116 tumours by G-573 was estimated to be 0.406? µM. The IC (50) values for tumour growth inhibition in HCT116 and H2122 were estimated to be 3.43 and 2.56?µM, respectively. ED (50) estimates in HCT116 and H2122 mouse xenograft models were estimated to be ~4.6 and 1.9?mg/kg/day, respectively.
Smiles
ClC1=CC=CC(=C1)C1=NC2=C(N1)C=CC=C2
Molecular Formula
C13H9ClN2
Molecular Weight
228.68
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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