SC-10914

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  SC10914 is a highly potent PARP inhibitor (PARP1 IC50 = 7.87 nM) with potent anti-proliferative activity against human BRCA deficient tumor cells (MDA-MB-436, BRCA1 deficient, IC50 = 4.03 nM, Capan-1 BRCA2 deficient, IC50 = 11.66 nM) and PTEN deficient tumor cells (HGC-27, PTEN deficient, IC50 = 0.35 ?M) . SC10914 showed potent anti-tumor activity in BRCA1/2 mutant tumor models and better pharmacokinetics profile has the potential to be selected as the clinical candidate for the treatment of treatment of BRCA1/2 deficient cancers.

• Smiles:

  NC(Cc1ccc(cc1)-c1ccccc1)C(O)=O

• Molecular Formula:

  C15H15NO2

• Molecular Weight:

  241.29

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  76985-08-5