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SC-10914

CAT: 0931-T71757-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T71757-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
76985-08-5
Target
Others
Related Pathways
Others
Bioactivity
SC10914 is a highly potent PARP inhibitor (PARP1 IC50 = 7.87 nM) with potent anti-proliferative activity against human BRCA deficient tumor cells (MDA-MB-436, BRCA1 deficient, IC50 = 4.03 nM, Capan-1 BRCA2 deficient, IC50 = 11.66 nM) and PTEN deficient tumor cells (HGC-27, PTEN deficient, IC50 = 0.35 μM) . SC10914 showed potent anti-tumor activity in BRCA1/2 mutant tumor models and better pharmacokinetics profile has the potential to be selected as the clinical candidate for the treatment of treatment of BRCA1/2 deficient cancers.
Smiles
NC(Cc1ccc(cc1)-c1ccccc1)C(O)=O
Molecular Formula
C15H15NO2
Molecular Weight
241.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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