Products for Research Use Only
RegisterLogin

GSK1370319A

CAT: 0931-T71651-01Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T71651-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1001389-31-6
Target
Others
Related Pathways
Others
Bioactivity
GSK1370319A is a potent P2X7 antagonist (IC50 = 3.2 nM) . GSK1370319A inhibits ATP-induced increase in IL-1β release and caspase 1 activation in lipopolysaccharide (LPS) -primed mixed glia by blocking assembly of the inflammasome in a pannexin 1-dependent manner. GSK1370319A also inhibits ATP-induced subregion-specific neuronal loss in hippocampal organotypic slice cultures, which is dependent on its ability to prevent inflammasome assembly in glia. Significantly, GSK1370319A attenuates age-related deficits in long-term potentiation (LTP) and inhibits the accompanying age-related caspase 1 activity. We conclude that inhibiting P2X (7) receptor-activated NLRP3 inflammasome formation and the consequent IL-1β release from glia preserve neuronal viability and synaptic activity.
Smiles
C(NCC1=C(Cl)C=C(Cl)C=C1)(=O)[C@H]2N(C)C(=O)CC2
Molecular Formula
C13H14Cl2N2O2
Molecular Weight
301.17
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

1001389-31-6

PubChem
cas1001389-31-6
modify2026-05-17
descriptionPurinergic P2X Receptor Antagonist; structure in first source
synonyms
GSK1370319A
(2S)-N-[(2,4-dichlorophenyl)methyl]-1-methyl-5-oxopyrrolidine-2-carboxamide
(2S)-N-((2,4-dichlorophenyl)methyl)-1-methyl-5-oxopyrrolidine-2-carboxamide
RefChem:922547GSK 1370319ACHEMBL22187591001389-31-6orb1737810SCHEMBL2581837GTPL10503+ 15 more
PubChem LinkClick here

Alternative Products

CatalogName
MBS5814189GSK1370319A

Popular Products