KOS-1584

CAT: 0931-T71577-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T71577-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1032119-44-0
Target
Others
Related Pathways
Others
Bioactivity
KOS-1584 is a second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to first-generation epothilones, this agent exhibits greater safety and efficacy with an enhanced pharmaceutical profile, including enhanced water solubility and tumor penetration, and reduced CNS exposure. In addition, epothilone KOS-1584 is a poor substrate for the P-glycoprotein (P-gp) drug efflux pump.
Molecular Formula
C27H39NO5S
Molecular Weight
489.67
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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MBS5814115KOS-1584
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