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RKS-262

CAT: 0931-T71549-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T71549-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1041469-97-9
Target
Others
Related Pathways
Others
Bioactivity
RKS262 is a specific cyclin/CDK inhibitor. RKS262 was identified by structural optimization of Nifurtimox which is currently undergoing phase II clinical trials to treat high-risk neuroblastoma. In a NCI (60) cell-line assay RKS262 exhibited significant cytotoxicity in ovarian cancer cells and a variety of other cell lines exceeding effects of commercial drugs such as cisplatin, 5-FU, cyclophosphamide or sapacitabine. Various leukemia cell-lines were most sensitive (GI (50) : ~ 10 nM) while several non-small cell lung cancer cell lines and few cell lines from other tissues were relatively resistant (GI (50) > 1 μM) to RKS262 treatment.
Smiles
ClC=1C=2C(OC(=O)C1C=NN3C(C)CS(=O)(=O)CC3)=CC=C(Br)C2
Molecular Formula
C15H14BrClN2O4S
Molecular Weight
433.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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