Oxaliplatin-d10

CAT: 0931-MF-0145585-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0145585-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1132819-16-9
Target
Apoptosis|||DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair|||Apoptosis|||Cell Cycle/Checkpoint
Bioactivity
Oxaliplatin-d10 is intended for use as an internal standard for the quantification of oxaliplatin by GC- or LC-MS. Oxaliplatin is a platinum-containing DNA-crosslinking agent. It induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein adducts, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells. Oxaliplatin is cytotoxic to cisplatin-sensitive A2780 (1A9) and KB-3-1 cells and cisplatin-resistant A2780-E (80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2.7 µM, respectively) . It reduces tumor growth in an HCCLM3 mouse xenograft model when administered at doses of 5 or 10 mg/kg once per week. Formulations containing oxaliplatin have been used in the treatment of advanced colorectal cancer and as adjuvants in stage III colon cancer.
Smiles
O=C1[O-][Pt+2]2([NH2][C@]3([C@]([NH2]2)(C(C(C(C3([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])[2H])[2H])[O-]C1=O
Molecular Formula
C8H4D10N2O4Pt
Molecular Weight
407.35
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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