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Phenylbutazone-d9

CAT: 0931-T71288-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0931-T71288-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1189479-75-1
Target
COX
Related Pathways
Neuroscience, Immunology/Inflammation
Bioactivity
Phenylbutazone-d9 is intended for use as an internal standard for the quantification of phenylbutazone by GC- or LC-MS. Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC50 = ~100 μM in the presence of hydrogen peroxide) . It also inhibits prostaglandin I synthase (IC50 = ~25 μM in the presence of hydrogen peroxide) . Phenylbutazone (2 mg/kg) reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-induced acute synovitis. Formulations containing phenylbutazone have been used in the treatment of lameness in horses.
Smiles
O=C1N(N(C(=O)C1C(C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])C2=CC=CC=C2)C3=CC=CC=C3
Molecular Formula
C19H11D9N2O2
Molecular Weight
317.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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