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ASP3662

CAT: 0931-T71243-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T71243-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1204178-50-6
Target
Others, Dehydrogenase
Related Pathways
Others, Metabolism
Bioactivity
ASP3662, also known as SPI-62, is a potent, selective and CNS-penetrable inhibitor of 11β-HSD1. The effects of ASP3662 suggest that selective inhibition of 11β-HSD1 may be an attractive approach for the treatment of neuropathic and dysfunctional pain, as observed in fibromyalgia. ASP3662 inhibited human, mouse and rat 11β-HSD1 but not human 11β-HSD2, in vitro. ASP3662 inhibited in vitro conversion of glucocorticoid from its inactive to active form in extracts of rat brain and spinal cord.
Smiles
CN1C(=NN=C1C(OC2=C(F)C=C(Cl)C=C2F)(C)C)C3=C(F)C=C(C(N)=O)C=C3
Molecular Formula
C19H16ClF3N4O2
Molecular Weight
424.8
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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