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Febrifugine

CAT: 0804-HY-N2384-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2384-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Febrifugine is a quinazolinone alkaloid that inhibits P. falciparum and has antimalarial activity. Febrifugine inhibits bladder cancer by inhibiting DNA synthesis, inducing apoptosis, and reducing steroids[1][2][3].
CAS Number
24159-07-7
UNSPSC
12352005
Hazard Statement
H301, H311, H331
Target
Apoptosis; DNA/RNA Synthesis; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/febrifugine.html
Purity
99.98
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1N(CC(C[C@H]2NCCC[C@@H]2O)=O)C=NC3=C1C=CC=C3
Molecular Formula
C16H19N3O3
Molecular Weight
301.34
Precautions
H301, H311, H331
References & Citations
[1]Herman JD, et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med. 2015 May 20;7 (288) :288ra77.|[2]Murata K, et al. Potentiation by febrifugine of host defense in mice against Plasmodium berghei NK65. Biochem Pharmacol. 1999 Nov 15;58 (10) :1593-601.|[3]Chen J, et al. Discovery of anticancer function of Febrifugine: Inhibition of cell proliferation, induction of apoptosis and suppression steroid synthesis in bladder cancer cells. Toxicol Appl Pharmacol. 2024 Mar;484:116878.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Plasmodium

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