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Famitinib malate

CAT: 0931-T71111-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T71111-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1256377-67-9
Target
Others, PDGFR, Apoptosis, VEGFR
Related Pathways
Tyrosine Kinase/Adaptors, Others, Apoptosis, Angiogenesis
Bioactivity
Famitinib malate (SHR1020) is an orally active multi-targeted kinase inhibitor that effectively inhibits the activity of c-kit, VEGFR-2, and PDGFRβ with IC50 values of 2.3 nM, 4.7 nM, and 6.6 nM, respectively. It induces cell apoptosis and demonstrates potent antitumor activity in human gastric cancer cells and xenografts, making it a valuable compound for cancer research.
Smiles
[C@H](CC(O)=O)(C(O)=O)O.C(=C\1/C=2C(NC1=O)=CC=C(F)C2)\C3=C(C)C4=C(N3)CCN(CCN(CC)CC)C4=O
Molecular Formula
C27H33FN4O7
Molecular Weight
544.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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