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ADMA-d6

CAT: 0931-T70990Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T70990Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1313730-20-9
Target
Endogenous Metabolite, NO Synthase
Related Pathways
Metabolism, Immunology/Inflammation
Bioactivity
NG, NG-dimethyl-L-arginine-d6 (ADMA-d6) (hydrochloride) is intended for use as an internal standard for the quantification of NG, NG-dimethyl-L-arginine by GC- or LC-MS. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS) . It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2) . ADMA levels are increased concomitant with an increase in blood pressure in Dahl salt-sensitive rats fed a high-salt diet. ADMA levels are increased in the plasma in a variety of endothelial dysfunction-related diseases, including hypertension, congestive heart failure, and end-stage renal disease.
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Cl.Cl.[2H]C([2H])([2H])N(C(=N)NCCC[C@H](N)C(O)=O)C([2H])([2H])[2H]
Molecular Formula
C8H14D6Cl2N4O2
Molecular Weight
281.2106
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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