BMY-42393

CAT: 0931-MF-0145175-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0145175-01Size:25 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
136451-58-6
Target
Prostaglandin Receptor|||Others
Related Pathways
Others|||Immunology/Inflammation|||GPCR/G Protein
Bioactivity
BMY-42393 is orally active and selective platelet aggregation inhibitor. BMY-42393 is also a prostacyclin partial agonist that inhibited ADP, collagen and thrombin-induced platelet aggregation (IC50 range 0.3 - 2.0 microM) . BMY-42393 stimulated platelet adenylate cyclase activity (EC50 = 25 nM) . Platelets treated with BMY 42393 showed an elevation of cAMP levels and activation of cAMP-dependent protein kinase. BMY 42393 also inhibited thrombin-induced elevation of intracellular free calcium. BMY 42393 competed for radiolabeled iloprost and PGE1 binding to platelet membranes (IC50; 170 nM and 130 nM, respectively) .
Smiles
C(CC1=CC(OCC(O)=O)=CC=C1)C2=NC(=C(O2)C3=CC=CC=C3)C4=CC=CC=C4
Molecular Formula
C25H21NO4
Molecular Weight
399.44
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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