Cabazitaxel-d6

• Target :

  Microtubule Associated|||Autophagy

• Related Pathways :

  Cytoskeletal Signaling|||Autophagy

• Bioactivity :

  Cabazitaxel-d6 is a deuterium labeled cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB) .

• Smiles :

  [H][C@@]12C[C@H](OC([2H])([2H])[2H])[C@@]3(C)C(=O)[C@H](OC([2H])([2H])[2H])C4=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c5ccccc5)[C@]3([H])[C@@]1(CO2)OC(C)=O)C4(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c1ccccc1

• Molecular Formula :

  C45H51D6NO14

• Molecular Weight :

  841.97

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1383561-29-2