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Duvelisib hydrate

CAT: 0931-T70802-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T70802-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1386861-49-9
Target
Others
Related Pathways
Others
Bioactivity
Duvelisib, also known as IPI-145 and INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration, PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike other isoforms of PI3K, the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and inflammatory and autoimmune diseases.
Smiles
O.C[C@H](Nc1ncnc2nc[nH]c12)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1
Molecular Formula
C22H19ClN6O2
Molecular Weight
434.884
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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