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CR-6086

CAT: 0931-T70718-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T70718-01Size:25 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1417742-86-9
Target
Others|||MMP|||Prostaglandin Receptor|||PD-1/PD-L1|||Interleukin
Related Pathways
Immunology/Inflammation|||GPCR/G Protein|||Apoptosis|||Cell Cycle/Checkpoint|||Others|||Proteases/Proteasome
Bioactivity
CR6086 is a novel, potent EP4 antagonist showing favourable immunomodulatory properties, striking DMARD effects in rodents, and anti-inflammatory activity targeted to immune-mediated inflammatory diseases and distinct from the general effects of cyclooxygenase inhibitors. CR6086 showed selectivity and high affinity for the human EP4 receptor (Ki = 16.6 nM) and functioned as a pure antagonist (half-maximal inhibitory concentration, 22 nM) on PGE2-stimulated cAMP production.
Smiles
N(C(=O)C1N(CC2=CC=C(C(F)(F)F)C=C2)CCC3(C1)CC3)C4(CC4)C5=CC=C(C(O)=O)C=C5
Molecular Formula
C26H27F3N2O3
Molecular Weight
472.5
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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