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Selonsertib HCl

CAT: 0931-T70622-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T70622-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1448428-05-4
Target
Others, MAPK, Apoptosis
Related Pathways
Apoptosis, Others, MAPK
Bioactivity
Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation.
Smiles
Cl.CC(C)n1cnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Molecular Formula
C24H25ClFN7O
Molecular Weight
481.96
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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