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Edicotinib HCl

CAT: 0931-T70444-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T70444-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1559069-92-9
Target
Others, c-Fms
Related Pathways
Tyrosine Kinase/Adaptors, Others
Bioactivity
Edicotinib, also known as JNJ-40346527, is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. FMS tyrosine kinase inhibitor JNJ-40346527 blocks the receptor-ligand interaction between FMS and its ligand CSF1, thereby preventing autophosphorylation of FMS. As a result, unphosphorylated FMS cannot activate FMS-mediated signaling pathways, thus potentially inhibiting cell proliferation in FMS-overexpressed tumor cells.
Smiles
Cl.CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CC(C)(C)OC(C)(C)C1
Molecular Formula
C27H36ClN5O2
Molecular Weight
498.07
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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A13008-5Edicotinib 5mg
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A13008-2Edicotinib 2mg
A13008-50Edicotinib 50mg
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