VUF14480

CAT: 0931-T70403-01Size: 25 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0931-T70403-01Size:25 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

CAS Number

1605304-31-1

Target

Others

Related Pathways

Others

Bioactivity

VUF14480 is a covalent partial agonist that interacts with cysteine 98 (3.36) of the human histamine H4 receptor. VUF14480 was shown to be a partial agonist of hH4 receptor-mediated G protein signalling and β-arrestin2 recruitment. VUF14480 bound covalently to the hH4 receptor with submicromolar affinity. Serine substitution of C98 (3.36) prevented this covalent interaction.

Smiles

C(=C)C=1N=C(C=C(N1)C2=CC=CC=C2)N3CCN(C)CC3

Molecular Formula

C17H20N4

Molecular Weight

280.37

Shipping Conditions

Ice Packs

Storage Temperature

-20°C