TOP1362

CAT: 0931-T70346-02Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0931-T70346-02Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1630203-25-6

Target

Others

Related Pathways

Others

Bioactivity

TOP1362 is a Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders. TOP1362 strongly inhibited the kinase targets p38α, Syk, Src, and Lck, blocked the rise in p38α expression in hyperosmolar Chang cells, and potently reduced inflammatory cytokine release in cellular models of innate and adaptive immunities. In the EIU model, TOP1362 dose-dependently attenuated the LPS-induced rise in inflammatory cell infiltration and ocular cytokine levels with efficacy comparable to that of dexamethasone.

Smiles

O(C=1C2=C(C(NC(NC3=C(OC)C(NS(C)(=O)=O)=CC(C(C)(C)C)=C3)=O)=CC1)C=CC=C2)C=4C=C(NC5=CC(C(NCCCN6CCOCC6)=O)=CC(OC)=C5)N=CC4

Molecular Formula

C43H51N7O8S

Molecular Weight

825.97

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl)ureido)naphthalen-1-yl)oxy)pyridin-2-yl)amino)-5-methoxy-N-(3-morpholinopropyl)benzamide

CAS Number	1630203-25-6
PubChem CID	86275224
IUPAC Name	3-[[4-[4-[[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]carbamoylamino]naphthalen-1-yl]oxy-2-pyridinyl]amino]-5-methoxy-N-(3-morpholin-4-ylpropyl)benzamide
Molecular Formula	C43H51N7O8S
Molecular Weight	826.0
XLogP	5.9
Topological Polar Surface Area	190
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	16
Heavy Atom Count	59
Formal Charge	0
Complexity	1440

SMILES

CC(C)(C)C1=CC(=C(C(=C1)NS(=O)(=O)C)OC)NC(=O)NC2=CC=C(C3=CC=CC=C32)OC4=CC(=NC=C4)NC5=CC(=CC(=C5)C(=O)NCCCN6CCOCC6)OC

InChI

InChI=1S/C43H51N7O8S/c1-43(2,3)29-24-36(40(56-5)37(25-29)49-59(6,53)54)48-42(52)47-35-12-13-38(34-11-8-7-10-33(34)35)58-31-14-16-44-39(27-31)46-30-22-28(23-32(26-30)55-4)41(51)45-15-9-17-50-18-20-57-21-19-50/h7-8,10-14,16,22-27,49H,9,15,17-21H2,1-6H3,(H,44,46)(H,45,51)(H2,47,48,52)

InChIKey

NIMKGKUGIJVPTM-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1630203-25-6

CID: 86275224

Formula: C43H51N7O8S

MW: 826.0

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	826.0
XLogP3	5.9
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	16
Exact Mass	825.35198278
Monoisotopic Mass	825.35198278
Topological Polar Surface Area	190 Å²
Heavy Atom Count	59
Formal Charge	0
Complexity	1440
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
MBS5812887	TOP1362

TOP1362

Chemical Information

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